Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives |
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Authors: | Ranjan Jana Tejas P Pathak Katrina H Jensen Matthew S Sigman |
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Institution: | Department of Chemistry, University of Utah , 315 South 1400 East, Salt Lake City, Utah 84112, United States. |
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Abstract: | A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity. |
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