KARI酶及其抑制剂

酮醇酸还原异构酶(Keto-Acid Reducto－Isomerase, KARI或称作乙酰羟基酸异构还原酶, Aceto-Hydroxyacid Isomero-Reductase, AHIR)是植物、微生物中的支链氨基酸生物合成途径中第二步的关键性酶。由于哺乳动物和人体内并不存在这种酶，因此靶向KARI酶的抑制剂具有安全、高效等特点，成为农用除草剂以及医药抗真菌药物的一个引人注目的研究方向。本文综述了KARI的酶学，KARI抑制剂及其抑制机理和理论研究进展，并对其发展趋势进行了展望。

Progress in KARI and its Inhibitors

With the development for nearly 20 years, the recordable optical disc products have achieved tremendous success in global market. The corresponding research for recording materials has been greatly promoted. The requirements for the recording materials include excellent thin-film optical characteristic, high recording sensitivity, favorable photo-thermal stability, and good film spin-coating performance. The organic compounds like cyanine, macrocyclic azotic compound, azo-metal complex, metal chelate, benzoheterocycle dye, have been applied to recordable optical discs as the recording materials. The properties pertinent to the recording materials will be adjusted appropriately according to the different working wavelengths of the three-generation recordable optical discs, infrared light CD-R, red light DVD±R and blue light BD-R/HD DVD-R. Through analyzing the growing route of dyes for CD-R and DVD±R, the macrocyclic azotic metal complex is indicated to be an important direction of development as the recording material for high density blue light recordable optical disc. To start up the R&D of recording materials is of great significance to our national optical memory industry. Research on dyes for CD-R can meet the pressing need for upgrading domestic recordable optical disc industry, and research on dyes for blue-ray disc could make China to be in the leading position of the new generation recordable optical disc format.