An efficient and highly selective deprotecting method for beta-(trimethylsilyl)ethoxymethyl ethers |
| |
Authors: | Chen Ming-Yi Lee Adam Shih-Yuan |
| |
Institution: | Department of Chemistry, Taipei Nursing College, Taipei, Taiwan 112. |
| |
Abstract: | A series of beta-(trimethylsilyl)ethoxymethyl ethers were hydrolyzed to their corresponding alcohols in high yields by using a catalytic amount of CBr4 (15%) in MeOH under refluxing reaction conditions. The chemoselective deprotection between trialkylsilyl and beta-(trimethylsilyl)ethoxymethyl-protected alcohols can be achieved by using an alcohol with steric hindrance such as iPrOH. The selectivity also can be achieved in the CBr4/MeOH reaction mixture under ultrasonic reaction conditions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|