| 一对手性Salen型席夫碱对映体的合成、结构与生物活性 |
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| 引用本文： | 郝洪庆,李鑫,孙静.一对手性Salen型席夫碱对映体的合成、结构与生物活性[J].无机化学学报,2013,29(6):1222-1226. |
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| 作者姓名： | 郝洪庆 李鑫 孙静 |
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| 作者单位： | 嘉应学院化学与环境学院,梅州 514015;嘉应学院化学与环境学院,梅州 514015;广东医学院药学院,东莞 523808 |
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| 基金项目： | 国家自然科学基金(No.21101077)和广东省自然科学基金(No. S2011040001705)资助项目。 |
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| 摘 要： | 采取分步反应法以1R,2R-环己二胺(或1S,2S-环己二胺)与2-羟基萘甲醛和水杨酸苯酯反应,合成了一对手性Salen型席夫碱对映体:1R-(2-羟基苯甲酰亚胺)-2R-(2-羟基萘甲亚胺)环己烷(1a)和1S-(2-羟基苯甲酰亚胺)-2S-(2-羟基萘甲亚胺)环己烷(1b),对其进行了单晶结构、圆二色光谱、元素分析、红外光谱表征及生物活性实验。单晶结构与圆二色光谱分析表明1a和1b互为对映体;生物活性实验显示1a具有一定的抑菌活性。
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| 关 键 词： | 手性 对映体 圆二色 生物活性 |
| 收稿时间： | 2012/6/24 0:00:00 |
| 修稿时间： | 1/4/2013 12:00:00 AM |
Synthesis, Structures and Biological Activities of Chiral Salen-Type Schiff Base Enantiomers |
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| HAO Hong-Qing,LI Xin and SUN Jing.Synthesis, Structures and Biological Activities of Chiral Salen-Type Schiff Base Enantiomers[J].Chinese Journal of Inorganic Chemistry,2013,29(6):1222-1226. |
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| Authors: | HAO Hong-Qing LI Xin and SUN Jing |
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| Institution: | School of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015 China;School of Chemistry and Environment, Jiaying University, Meizhou, Guangdong 514015 China;School of Pharmacy, Guangdong Medical College, Dongguan, Guangdong 523808 China |
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| Abstract: | Two chiral Salen-type Schiff base enantiomers, 1R-(2-hydroxy benzimine)-2R-(2-hydroxy naphthylmethylenimine) cyclohexane (1a) and 1S-(2-hydroxy benzimine)-2S-(2-hydroxy naphthylmethylenimine) cyclohexane (1b), synthesized though the solution reactions of phenyl salicylate, trans-1, 2-diaminocyclohexane and 2-hydroxynaphthalene-1-carbaldehyde in 2-propanol, have been characterized by EA, IR, X-ray crystallography, Circular Dichroism (CD) spectrum and biological tests. X-ray crystallography and CD spectrum reveal 1a and 1b are optically chiral enantiomers. Biological tests show that 1a has inhibiting bacteria effects. CCDC: 932330, 1; 932331, 2. |
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| Keywords: | chiral enantiomer circular dichroism biological activity |
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