| 化学品安全性快速评价方法 |
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| 引用本文： | 尹志刚,宋学谦,赵德丰. 化学品安全性快速评价方法[J]. 化学通报, 2003, 66(4): 241-246 |
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| 作者姓名： | 尹志刚 宋学谦 赵德丰 |
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| 作者单位： | 大连理工大学精细化工国家重点实验室,大连,116012;郑州轻工业学院化工系,郑州,450002;郑州轻工业学院化工系,郑州,450002;大连理工大学精细化工国家重点实验室,大连,116012 |
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| 基金项目： | 国家自然科学基金资助项目 ( 2 9972 0 0 6) |
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| 摘 要： | 简要评述了化学品安全性的传统评价方法。详细介绍了一种快速评价化学品安全性的重要方法——诱变性测试法。该方法选用几种标准(或特定)的鼠伤寒沙门氏菌(Salmonella typhimurium)作为观察对象来研究待测化学品对菌株的诱变情况，以菌株回复突变的数目表征待测化学品的诱变性。当回复突变数目为零剂量(化学品)的2倍以上时，所测定化学品具有诱变性。具有诱变性的化学品为不安全化学品。
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| 关 键 词： | 毒性 致癌性 诱变性测试 鼠伤寒沙门氏菌 |
| 修稿时间： | 2002-06-24 |
Fast Method for Evaluating the Security of Chemicals |
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| Yin Zhigang ,,Song Xueqian ,Zhao Defeng. Fast Method for Evaluating the Security of Chemicals[J]. Chemistry, 2003, 66(4): 241-246 |
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| Authors: | Yin Zhigang Song Xueqian Zhao Defeng |
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| Affiliation: | Yin Zhigang 1,2,Song Xueqian 2,Zhao Defeng 1* |
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| Abstract: | The present paper covers the comment on the traditional methods for evaluating the security of chemicals and the modern evaluating method referred to as Ames Test or Ames/Salmonella Assay which is based on the use of several strains of the bacteria Salmonella typhimurium. The procedure detects reverse mutations that occur in these strains in the presence of a test chemical. The mutagenic activity of the test chemical will be given in a quantitative measure on the revertants. A test chemical is considered to be mutagenic and insecure when the number of the revertants per plate is at least two times the base count (zero dose of the test chemical). |
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| Keywords: | Toxicity Carcinogenesis Ames Test or Ames/Salmonella assay Salmonella typhimurium |
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