| 三明治结构rGO/Fe3O4@mSiO2载体的构筑及协同抗肿瘤性能 |
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| 引用本文： | 杨永梅,嵇眀翔,杨颖,谢安建,沈玉华.三明治结构rGO/Fe3O4@mSiO2载体的构筑及协同抗肿瘤性能[J].无机化学学报,2018,34(6):1095-1102. |
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| 作者姓名： | 杨永梅 嵇眀翔 杨颖 谢安建 沈玉华 |
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| 作者单位： | 安徽大学化学化工学院现代生物制造协同创新中心;黄山学院化学化工学院 |
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| 基金项目： | 国家自然科学基金（No.21571002，21671001）和安徽省高校优秀青年骨干人才国内外访学项目（No.gxfx2017105）资助。 |
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| 摘 要： | 采用温和的反应条件,制备出三明治结构rGO/Fe_3O_4@mSiO_2,利用SEM、TEM、FTIR、XRD和N_2吸附-脱附等对其形貌和性能进行表征,考查了其对Hela细胞的毒性和细胞荧光成像效果,并探讨了其形成机理。实验结果表明:rGO/Fe_3O_4@mSiO_2具有较高的比表面积(217 m~2·g~(-1)),对抗癌药物五氟尿嘧啶(5-FU)的载药率达到57.34%;它还具有较好的磁性,磁饱和强度为32 emu·g-1;而且rGO/Fe_3O_4@mSiO_2纳米复合物在光照条件下具有优异的光热转换性能,对He La细胞表现出明显的杀伤效果。
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| 关 键 词： | 纳米复合材料 磁靶向 光热治疗 药物载体 协同抗癌 |
| 收稿时间： | 2018/3/16 0:00:00 |
| 修稿时间： | 2018/4/17 0:00:00 |
Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers |
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| YANG Yong-Mei,JI Ming-Xiang,YANG Ying,XIE An-Jian and SHEN Yu-Hua.Construction and Synergistic Anticancer Efficacy of Sandwich-like rGO/Fe3O4@mSiO2 Drug Carriers[J].Chinese Journal of Inorganic Chemistry,2018,34(6):1095-1102. |
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| Authors: | YANG Yong-Mei JI Ming-Xiang YANG Ying XIE An-Jian and SHEN Yu-Hua |
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| Institution: | School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China;School of Chemistry and Chemical Engineering, Huangshan University, Huangshan, Anhui 245041, China,School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China,School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China,School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China and School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei 230601, China |
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| Abstract: | A novel sandwich-like nanocomposites of rGO/Fe3O4@mSiO2 were successfully fabricated through a facile method. The morphology and properties of nanocomposites were characterized by SEM, TEM, FTIR, XRD and N2 adsorption-desorption. As a result, it was observed that the nanocomposites exhibit the saturation magnetization of 32 emu·g-1, and possess abundant pores with a large surface area as much as 217 m2·g-1. The loading capacity of Pentafluorouracil (5-FU) with the nanocomposites was high(57.34%). The formation mechanism of rGO/Fe3O4@mSiO2 was discussed. Additionally, the synergistic anticancer efficacy of as-prepared nanocomposites against HeLa cell line was investigated by MTT assay and cell fluorescence microscopic imaging analysis. The results indicated that 5-FU loaded in the nanocoposites is effectively delivered to tumor lesion sites under the action of magnetic targeting. Moreover, the rGO/Fe3O4@mSiO2 nanocomposites have excellent photothermal conversion properties under light conditions, and show significant killing effect on HeLa cells. |
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| Keywords: | nanocomposite magnetic targeting photo-thermal therapy drug carrier synergistic anti-cancer |
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