含1,2,3-噻二唑的邻甲酰胺基苯甲酰胺类化合物的合成、晶体结构与生物活性

以取代邻氨基苯甲酸为起始原料, 设计并合成了一系列未见文献报道的含1,2,3-噻二唑的邻甲酰胺基苯甲酰胺类化合物. 所有化合物的结构均经元素分析和1H NMR确证, 并且采用X射线单晶衍射分析方法测定了化合物7g的结构. 初步的生物活性试验结果表明, 部分化合物具有一定的杀菌活性.

Synthesis, Crystal Structure and Biological Activity of Novel Anthranilic Diamides Containing 1,2,3-Thiadiazole

Since the public introduction of phthalic acid diamides and anthranilic diamides by Nihon Nohyaku,Bayer CropScience and DuPont,respectively,diamides have been the focus of synthesis in the field of agrochemical industry.Especially anthranilic diamides as insecticides,furthermore which also displayed good herbicidal and fungicidal activities,have recently attracted considerable attention.In the investigation of new agrochemicals,1,2,3-thiadiazole derivatives often display good biological activities,and some diamides containing 1,2,3-thiadiazole possess good insecticide and fungicidal activities.In order to search for novel diamides which have high activities,a series of novel anthranilic diamides containing 1,2,3-thiadiazole were designed and synthesized,their structures were identified by means of elemental analysis,1H NMR,and the structure of compound 7g was determined by X-ray single crystal diffraction method.The preliminary results of biological activity experiment show that some of the title compounds exhibited a favourable fungicidal activity.