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Thermoanalytical study of glibenclamide and excipients
Authors:G. G. G. Oliveira  H. G. Ferraz  J. S. R. Matos
Affiliation:(1) Department of Pharmacy, College of Pharmaceutical Sciences, Universidade de São Paulo, SP, Brazil;(2) Department of Pharmacy, College of Pharmaceutical Sciences, Universidade de São Paulo, SP, Brazil;(3) Department of Elementar Chemistry, Chemistry Institute, Universidade de São Paulo, SP, Brazil
Abstract:Summary Taking into account the problems of desertification and agricultural practices able to provide income to the population at the semi-arid region of North-East Brazil, this work presents the results of the chemical and thermal characterization by TG and DSC of the seed derivatives of Italicrdquo>Cnidoscolus quercifolius, hereinafter called faveleira, aiming at the application of these materials as an alternative of food source for animals and for the human population at this region. The faveleira seed derivatives present thermodynamic properties similar to the ones of other foods utilized for human use, as well as an acceptable calorific value. According to TG and DSC results, was verified that the faveleira derivatives presents good thermal and oxidative stabilities.
Keywords:glibenclamide  TG  DSC  compatibility  isothermal kinetics  pharmaceuticals  glyburide  magnesium stearate
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