Electrophoresis of mutant proteins in inherited diseases |
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Authors: | Y Suzuki |
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Affiliation: | Tokyo Metropolitan Institute of Medical Science, Japan. |
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Abstract: | The electrophoretic approaches for detection of mutant proteins in inherited diseases are briefly reviewed and discussed. Mutation of a protein, known to be associated with a specific inherited disease, is detected by immunoblotting, immunoprecipitation or enzyme staining, combined with various electrophoretic techniques. Some instrumental and technological devices for two-dimensional electrophoresis have been reported for the screening of mutant proteins in diseases of currently unknown etiology. |
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