Borondipyrromethene-derived Cu2+ sensing chemodosimeter for fast and selective detection |
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Authors: | Zhao Chunchang Feng Peng Cao Jian Wang Xuzhe Yang Yang Zhang Yulin Zhang Jinxing Zhang Yanfen |
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Affiliation: | Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science & Technology, Shanghai 200237, PR China. zhaocchang@ecust.edu.cn |
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Abstract: | Here, we report a new Cu(2+)-selective fluorescent turn-on probe BODIPY-EP, in which the 2-pyridinecarboxylic acid is connected to a 6-hydroxyindole-based BODIPY platform through an ester linkage. The ester bond of BODIPY-EP is selectively hydrolyzed by the reaction with Cu(2+) under mild and neutral conditions to generate BODIPY-OH, showing strong characteristic fluorescence of BODIPY-OH. The favorable features of BODIPY-EP towards Cu(2+) include fast response, large fluorescence enhancement and high selectivity. We further demonstrated that the membrane-permeable probe reacts with intracellular Cu(2+) and exhibits bright fluorescence in living cells. |
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