An approach to α-substituted amines |
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Authors: | Lorenzo Williams Susan E Booth Kjell Undheim |
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Institution: | Lorenzo Williams, Susan E. Booth,Kjell Undheim* |
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Abstract: | A number of amines have been alkylated at the position alpha to nitrogen via free radical methodology. N-(2-Iodobenzyl) and N-(2-iodobenzoyl)‘protected’ amines have been used to generate radicals which rapidly undergo a 1,5-hydrogen shift to give more stable α-amino radicals. These can subsequently be trapped by electron deficient alkenes to give α-alkylated amines. |
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