Introduction of a triazole amino acid into a peptoid oligomer induces turn formation in aqueous solution |
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Authors: | Pokorski Jonathan K Jenkins Lisa M Miller Feng Hanqiao Durell Stewart R Bai Yawen Appella Daniel H |
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Institution: | Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. |
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Abstract: | Peptoids are a non-natural class of oligomers that are composed of repeating N-substituted glycine units and are capable of folding into helices that mimic peptide structure and function. In this letter, we report the concise synthesis of a 1,5-substituted triazole amino acid (Tzl) and its subsequent incorporation into a short peptoid. The Tzl amino acid was shown to induce turn formation in aqueous solution, thus expanding the structural repertoire available to peptoid chemists. |
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