First highly stereoselective synthesis of anti-alpha-trifluoromethyl-beta-amino acid derivatives |
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| Authors: | Shimada Taichi Yoshioka Masamitsu Konno Tsutomu Ishihara Takashi |
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| Affiliation: | Department of Chemistry and Materials Technology, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan. |
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| Abstract: | The Reformatsky-type reaction of 2-bromo-3,3,3-trifluoropropanoic imide with various types of imines, in the presence of ZnBr2 as a Lewis acid in THF at 0 degrees C for 3 h, gave the corresponding alpha-trifluoromethyl-beta-amino acid derivatives in a highly anti-selective manner. |
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