| 2-芳甲酰氨基硫羰基-3-异噻唑酮及4-氰基-5-甲硫基-2-芳甲酰氨基硫羰基-3-异噻唑酮的合成与生物活性 |
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| 引用本文： | 杨小平,李正名,陈寒松,刘洁,李树正.2-芳甲酰氨基硫羰基-3-异噻唑酮及4-氰基-5-甲硫基-2-芳甲酰氨基硫羰基-3-异噻唑酮的合成与生物活性[J].高等学校化学学报,1999,20(3):395-398. |
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| 作者姓名： | 杨小平 李正名 陈寒松 刘洁 李树正 |
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| 作者单位： | 南开大学元素有机化学国家重点实验室, 南开大学元素有机化学研究所, 天津 300071 |
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| 摘 要： | 通过3-羟基异噻唑(4)和4-氰基-5-甲硫基-3-羟基异噻唑(5)分别与芳酰基异硫氰酸酯(3)反应,合成标题化合物2-芳甲酰氨基硫羰基-3-异噻唑酮(6a_6f)和4-氰基-5-甲硫基-2-芳甲酰氨基硫羰基-3-异噻唑酮(7a_7e),对此反应及产物的结构特点进行了探讨.
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| 关 键 词： | 异噻唑 酰基硫脲 合成 杀菌活性 |
| 收稿时间： | 1998-04-24 |
| 修稿时间： | 1998-04-24. |
Syntheses and Biological Activities of 2-Arylamidothioacyl-3-isothiozolones and 4-Cyano-5-methylthio-2-arylamidothioacyl-3-isothiozolones |
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| YANG Xiao-Ping,LI Zheng-Ming,CHEN Han-Song,LIU Jie,LI Shu-Zheng.Syntheses and Biological Activities of 2-Arylamidothioacyl-3-isothiozolones and 4-Cyano-5-methylthio-2-arylamidothioacyl-3-isothiozolones[J].Chemical Research In Chinese Universities,1999,20(3):395-398. |
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| Authors: | YANG Xiao-Ping LI Zheng-Ming CHEN Han-Song LIU Jie LI Shu-Zheng |
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| Institution: | Research Institute of Elementoorganic Chemistry, Key Laboratory of Elementoorganic Chemistry, Nankai University, Tianjin, 300071 |
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| Abstract: | Novel compounds, 2arylamidothioacyl3isothiozolones 6 and 4cyano5methylthio2arylamidothioacyl3isothiozolones 7Z] were synthesized by reacting of 3hydroxyisothiozoles( 4, 5 ) with aryl isothiocyanates 3 . The unique coupling constants of 4H and 5H of isothiazole ring of compounds 6 were discovered and explained according to the coplanarity of isothiazole ring with thioacyl group. The preliminary test of fungicidal activity showed that some of the title compounds possessed promising activity. |
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| Keywords: | Isothiozole Acyl thiourea Synthesis Fungicidal activity |
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