Synthesis and antifungal activity of rhodopeptin analogues. 2. Modification of the west amino acid moiety |
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| Authors: | Nakayama K Kawato H C Inagaki H Nakajima R Kitamura A Someya K Ohta T |
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| Affiliation: | New Product Research Laboratories I, Daiichi Pharmaceutical Co. Ltd, Tokyo, Japan. |
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| Abstract: | Structure-activity relationships of the west amino acid modified analogues of rhodopeptins, novel antifungal tetrapeptide isolated from Rhodococcus species Mer-N1033, have been investigated. Among the analogues synthesized, 2,2-difluoro and 2-hydroxy derivatives retained the antifungal activity with better physical properties, i.e., solubility or acute toxicity. |
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