Exiguaquinol: a novel pentacyclic hydroquinone from Neopetrosia exigua that inhibits Helicobacter pylori MurI |
| |
Authors: | de Almeida Leone Priscila Carroll Anthony R Towerzey Leanne King Gordon McArdle Bernadette M Kern Gunther Fisher Stewart Hooper John N A Quinn Ronald J |
| |
Institution: | Eskitis Institute, Griffith University, Brisbane, QLD, Australia. |
| |
Abstract: | Bioassay-guided fractionation of the methanol extract of the Australian sponge Neopetrosia exigua led to the isolation of exiguaquinol (2), a new pentacyclic hydroquinone that inhibited Helicobacter pylori glutamate racemase (MurI) with an IC(50) of 4.4 microM. Its structure and relative configuration were assigned on the basis of spectroscopic data. Exiguaquinol (2), bearing a novel pentacyclic ring skeleton, is the first natural product to show inhibition of H. pylori MurI. Its protein-ligand modeling is also discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|