Improved methodologies for the preparation of highly substituted pyridines |
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Authors: | Fernández Sainz Yolanda Raw Steven A Taylor Richard J K |
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Affiliation: | Department of Chemistry, University of York, Heslington, York YO10 5DD, UK. |
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Abstract: | [reaction: see text] Two separate strategies have been developed for the preparation of highly substituted pyridines from 1,2,4-triazines via the inverse-electron-demand Diels-Alder reaction: a microwave-promoted, solvent-free procedure and a tethered imine-enamine (TIE) approach. Both routes avoid the need for a discrete aromatization step and offer significant advantages over the classical methods, giving a wide variety of tri-, tetra-, and penta-substituted pyridines in high, optimized yields. |
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