Spectrophotometric determination of piroxicam |
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| Authors: | Zh. A. Kormosh I. P. Hunka Y. R. Bazel |
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| Affiliation: | 1.Lesya Ukrainka Volyn State University,Lutsk,Ukraine;2.Pavel Jozef ?afarik University at K?sice,K?sice,Slovak Republic;3.Chemistry Department,Uzhgorod National University,Uzhgorod,Ukraine |
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| Abstract: | The possibility of the spectrophotometric determination of piroxicam based on the extraction of its ion associate (IA) with the polymethine dye, 5-thiocyanate-1,3,3-trimethyl-2[(1E)-3-[(2E)-1,3,3-trime-thyl-1-H-indol-2-ilidine]-propenyl]-3H-indolium chloride. The maximal recovery of IA with toluene is achieved when pH of the aqueous phase is 8.0–12.0 and the concentration of the dye is (1.0–2.0) × 10−4. The molar absorption coefficient of IA is 8 × 104, the detection limit of piroxicam is 0.49 μg/mL. A procedure has been developed for the extraction-spectrophotometric determination of piroxicam in the concentration range 1.0–20.0 μg/mL. |
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