Interferences in clinical capillary zone electrophoresis of serum proteins |
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Authors: | Bossuyt Xavier |
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Institution: | Laboratory Medicine/Immunology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. xavier.bossuyt@uz.kuleuven.ac.be |
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Abstract: | Capillary zone electrophoresis (CZE) of serum proteins has become a well-accepted method for the separation of serum proteins and for the detection of monoclonal proteins in clinical laboratories. As CZE uses ultraviolet detection for direct protein quantification, exogenous ultraviolet-absorbing substances are a novel challenge, not present in conventional gel-based methods in which protein is quantified by dye binding. This minireview gives a survey of interfering substances, including iodinated contrast agents and antibiotics. |
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