11/9-mixed helices in the alpha/beta-peptides derived from alternating alpha- and beta-amino acids with proteinogenic side chains |
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| Authors: | Srinivasulu Gannoju Kumar Singarapu Kiran Sharma Gangavaram V M Kunwar Ajit C |
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| Affiliation: | Centre for Nuclear Magnetic Resonance and D-211, Discovery Laboratory, Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India. |
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| Abstract: | alpha/beta-Hybrid peptides are prepared from amino acids with proteinogenic side chains on the basis of the concept of "alternating chirality", involving D-Phe and a beta3-hVal. Through the extensive NMR, CD, and MD studies, robust left-handed 11/9-mixed helices were identified in these peptides in CDCl3 solutions, wherein the 11/9-mixed helix was observed even in a small peptide with three residues. |
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