| A New Polyphenolic Compound from Rubus aleaefolius and Its Inhibitory Activity on Mammalian Cell Cycle at G0／G1 Phase |
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| 引用本文： | ChengBinCUI QingChunZHAO 等.A New Polyphenolic Compound from Rubus aleaefolius and Its Inhibitory Activity on Mammalian Cell Cycle at G0／G1 Phase[J].中国化学快报,2002,13(4):327-330. |
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| 作者姓名： | ChengBinCUI QingChunZHAO |
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| 作者单位： | [1]BeijingInstituteofBiomedicine,Beijing100091 [2]ShenyangPharmaceuticalUniversity,Shenyang110016 |
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| 基金项目： | 国家自然科学基金，the Found from Ministry |
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| 摘 要： | Rubuphenol (1), a new polyphenolic compound, was isolated together with the known ellagic acid (2) as new cell cycle inhibitors from Rubus aleaefolius Poir. Through a bioassay-guided separation procedure and the structure of 1 was elucidated by spectroscopic method. Compounds 1 and 2 inhibited the cel cycle of tsFT210 cells at the G0/G1 phase respectively with the MIC values of 14.6μM and 10.3μM.
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| 关 键 词： | 多酚化合物 悬钩子属植物 哺乳动物 抑制活性 细胞周期 |
A New Polyphenolic Compound from Rubus aleaefolius and Its Inhibitory Activity on Mammalian Cell Cycle at G0/G1 Phase |
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| Cheng Bin CUI,Qing Chun ZHAO,Bing CAI,Xin Sheng YAO,Hiroyouki OSADA.A New Polyphenolic Compound from Rubus aleaefolius and Its Inhibitory Activity on Mammalian Cell Cycle at G0/G1 Phase[J].Chinese Chemical Letters,2002,13(4):327-330. |
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| Authors: | Cheng Bin CUI Qing Chun ZHAO Bing CAI Xin Sheng YAO Hiroyouki OSADA |
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| Abstract: | Rubuphenol (1), a new polyphenolic compound, was isolated together with the known ellagic acid (2) as new cell cycle inhibitors from Rubus aleaefolius Poir. through a bioassay-guided separation procedure and the structure of 1 was elucidated by spectroscopic method. Compounds 1 and 2 inhibited the cell cycle of tsFT210 cells at the G0/G1 phase respectively with the MIC values of 14.6 mM and 10.3 mM. |
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| Keywords: | Rubuphenol ellagic acid polyphenol Rubus aleaefolius cell cycle inhibitor |
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