Catalytic enantioselective fluorination of beta-keto esters by phase-transfer catalysis using chiral quaternary ammonium salts |
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Authors: | Kim Dae Young Park Eun Joo |
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Affiliation: | Department of Chemistry, Soonchunhyang University, Asan P.O. Box 97, Chungnam 336-600, Korea. dyoung@sch.ac.kr |
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Abstract: | [reaction: see text] The catalytic enantioselective electrophilic fluorination promoted by quaternary ammonium salt from cinchonine as a phase-transfer catalyst is described. Treatment of beta-keto esters with N-fluorobenzenesulfonimide as the fluorine source under mild reaction conditions afforded the corresponding alpha-fluoro beta-keto esters in exellent yields with good to moderate enantiomeric excesses |
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