Regiocontrolled synthesis of the trimeric quinone framework of conocurvone |
| |
Authors: | Emadi Ashkan Harwood John S Kohanim Sahar Stagliano Kenneth W |
| |
Institution: | Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, Chicago, Illinois 60616, USA. |
| |
Abstract: | reaction: see text] The trimeric quinone framework of conocurvone is crucial for its potent anti-HIV activity. A new synthesis of trimeric quinones based on stepwise substitution of the halogens in 2,3-dihaloquinones by hydroxyquinone anions is described. Chlorinated biquinones are key intermediates that undergo regiospecific substitution reactions to yield trimeric quinone monomethyl ethers. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|