Synthesis of the C1-C21 (C1'-C21') fragment of the dimeric polyketide natural product SCH 351448 |
| |
Authors: | Bhattacharjee Ashoke Soltani Omid De Brabander Jef K |
| |
Institution: | Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038, USA. |
| |
Abstract: | structure: see text] A convergent, stereoselective assembly of the C1-C21 (C1'-C21') fragment of SCH 351448, a 28-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles 75% of the carbon skeleton and all the stereochemical elements present in the natural product. In addition, an interesting boron ligand effect on the diastereoselectivity of a key aldol reaction with methyl ketone-derived enolborinates is reported. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|