Vilsmeier-Haack reactions of 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans toward the synthesis of highly substituted pyridin-2(1H)-ones |
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| Authors: | Xiang Dexuan Yang Yang Zhang Rui Liang Yongjiu Pan Wei Huang Jie Dong Dewen |
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| Affiliation: | Department of Chemistry, Northeast Normal University, Changchun, 130024, China. |
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| Abstract: | A facile and efficient one-pot synthesis of highly substituted pyridin-2(1H)-ones was developed via Vilsmeier-Haack reactions of readily available enaminones, 2-arylamino-3-acetyl-5,6-dihydro-4H-pyrans, and a mechanism involving sequential ring-opening, haloformylation, and intramolecular nucleophilic cyclization reactions is proposed. |
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