3,7-Dimethylguanine, a new purine from a Philippine sponge Zyzzya fuliginosa. |
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| Authors: | D Tasdemir G C Mangalindan G P Concepción M K Harper C M Ireland |
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| Institution: | Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA. cireland@deans.pharma.utah.edu |
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| Abstract: | A new purine 3,7-dimethylguanine (1) has been isolated from the marine sponge Zyzzya fuliginosa, along with the known metabolites, makaluvamines A, C, K (2--4), 4-hydroxyphenylacetic acid (5), methyl ester of 4-hydroxyphenylacetic acid (6), 4-hydroxyphenethyl alcohol (7), L-phenylalanine (8) and L-tryptophan (9). The structure of 3,7-dimethylguanine (1) was elucidated by analysis of 1D and 2D (one- and two-dimensional) NMR HMQC (heteronuclear multiple quantum coherence), gHMBC (heteronuclear multiple bond connectivity), 1H-15N gHMBC] data, mass spectroscopy data, and by comparison with 3,7-dimethylisoguanine (10). |
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