Selective oxidation of acetylenic 1,4-diols with dioxiranes in comparison with the methyltrioxorhenium-hydrogen peroxide oxidant |
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Authors: | Lucia D&rsquo Accolti |
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Affiliation: | Dipartimento Chimica, Università di Bari, v. Amendola 173, I-70126 Bari, Italy C.N.R.—Istituto di Chimica dei Composti Organometallici (ICCOM), Bari Section, Italy |
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Abstract: | Dimethyldioxirane (1a) and its trifluoro analog (1b) were employed to achieve selectively the direct transformation of hex-3-yne-2,5-diol 3a and 1,4-diphenyl-but-2yne-1,4-diol 3b (two representative acetylenic 1,4-diols) into the corresponding carbonyls, leaving the carbon-carbon triple bond moiety untouched. The results are compared with those recorded in the analogous oxidation using the methyltrioxorhenium (MTO)/85% H2O2 homogeneous system. The powerful methyl(trifluoromethyl)dioxirane (1b) is the reagent of choice to achieve optimum yields of the target alkyne-1,4-diones, which are extremely versatile synthons. |
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Keywords: | Dioxiranes Dimethyldioxirane Methyl(trifluoromethyl)dioxirane Methyltrioxorhenium Hydrogen peroxide Acetylenic 1,4-diols Oxidation |
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