Ti(III)-induced radical cyclization. A stereoselective entry to the perhydrobenzo[e]indene unit of new protein farnesyltransferase inhibitors, andrastins A-D |
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| Authors: | Masahiro Toyota |
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| Institution: | Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobaya, Sendai 980-8578, Japan |
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| Abstract: | An efficient approach for the synthesis of a fully functionalized perhydrobenzoe]indene, the BCD ring system of andrastins A-D, is described. The synthesis commences from (±)-Wieland-Miescher ketone and features a Ti(III)-induced radical cyclization as the central step. |
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| Keywords: | Ti(III)-induced radical cyclization Andrastins Protein farnesyltransferase inhibitor |
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