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A versatile synthesis of fused triazolo derivatives by sequential Ugi/alkyne-azide cycloaddition reactions |
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| Authors: | Irini Akritopoulou-Zanze Vijaya Gracias Stevan W. Djuric |
| Affiliation: | Scaffold-Oriented Synthesis, Abbott Laboratories, R4CP, AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA |
| Abstract: | We report a facile synthesis of fused dihydrotriazolo[1,5-a]pyrazinones and triazolobenzodiazepines by an Ugi/alkyne-azide cycloaddition synthetic sequence. The coupling of the Ugi multi-component reaction with the intramolecular alkyne-azide cycloaddition provides access to highly functionalized heterocyclic ring systems in two steps from easily available starting materials in excellent overall yields. |
| Keywords: | Multi-component reactions Ugi Intramolecular azide-alkyne cycloaddition Fused triazolo derivatives Dihydrotriazolo[1,5-a]pyrazinones Triazolobenzodiazepines Sequential Ugi/IAAC Fused heterocycles |
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