An efficient synthesis of the intrinsic fluorescent peptide labels, (S)- and (R)-(6,7-dimethoxy-4-coumaryl)alanines via asymmetric hydrogenations |
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| Authors: | Wei Wang Hao Li |
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| Institution: | Department of Chemistry, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA |
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| Abstract: | The title compounds 1a,b are efficiently synthesized in high yields and with high enantioselectivity (>95% ee) by using a sequence in which the key step involves asymmetric hydrogenation of dehydroamino methyl ester 4 with Burk’s DuPHOS-based Rh(I) catalysts. |
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| Keywords: | Asymmetric hydrogenation DuPHOS Fluorescent label Coumarin |
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