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Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions |
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| Authors: | Lisa A. Liotta Irene Medina Jennifer L. Robinson Po-Shen Pan Jennifer V.C. Johnston Fiona A. Curtis Shelli R. McAlpine |
| Affiliation: | a Department of Chemistry and Biochemistry, 5500 Campanile Dr., San Diego State University, San Diego, CA 92182-1030, USA b Centre for Infectious Diseases, Wolfson Research Institute, University of Durham, Queen’s Campus, Stockton-on-Tees TS17 6BH, UK |
| Abstract: | Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics. |
| Keywords: | Macrocycles Peptides Antibiotics Holliday junction Macrocyclic peptides C-2 symmetrical |
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