Diastereoselective synthesis of the 19-epi-C18-C25 segment of (−)-lasonolide A and an unusual inversion at C19期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

*Diastereoselective synthesis of the 19-epi-C₁₈-C₂₅ segment of (−)-lasonolide A and an unusual inversion at C₁₉*

Authors:	Tomoyuki Yoshimura

Affiliation:	Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan

Abstract:	Diastereoselective construction of the 19-epi-C₁₈-C₂₅ segment of (−)-lasonolide A was achieved using a 5-exo-trigonal mode of radical cyclization for the creation of the contiguous quaternary and tertiary stereogenic centers at C₂₂ and C₂₃ as the key reaction step. During the dehydration stage, it was found that an unusual inversion of configuration took place.

Keywords:	Polyketide Lasonolide A Radical cyclization Inversion Tamao oxidation
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