A new fluorescent metal sensor with two binding moieties |
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| Authors: | Asuka Ohshima Tatsuo Arai |
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| Institution: | a Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1, Tennodai, Tsukuba-city, Ibaraki 305-8571, Japan
b Research Facility Centre for Science and Technology, University of Tsukuba, 1-1-1, Tennodai, Tsukuba-city, Ibaraki 305-8571, Japan |
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| Abstract: | A new fluorescent chelator Oxa, having two metal-binding sites, was designed and synthesized in six steps. Oxa exhibited two distinctive dissociation constants for Zn2+ ( μM and  μM), with considerable fluorescence increase in aqueous buffer at pH 7.2. Affinities of Oxa for the other biologically important ions such as Ca2+ ( μM and  mM) and Mg2+ ( μM and  could not be determined) in the same conditions were also obtained. |
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| Keywords: | Fluorescent sensors Complexation |
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