An improved protocol for the SmI2-promoted C-alkylation of peptides: degradation and functionalization of serine residues in linear and cyclic peptides |
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| Authors: | Peter Blakskjær |
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| Institution: | Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark |
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| Abstract: | The utility of the samarium diiodide promoted C-alkylation of peptides for the introduction of new side chains on peptide strands is dramatically enhanced by the initial oxidative degradation of serine residues in small peptides. In this way, cyclic peptides may also be included in this repertoire as a method for the preparation of peptide libraries. |
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| Keywords: | Peptides Serine Oxidative degradation Samarium diiodide C-Alkylation |
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