An asymmetric dihydroxylation route to (2S,3S)-3-hydroxypipecolic acid |
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Authors: | Mandar S. Bodas |
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Affiliation: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India |
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Abstract: | A concise enantioselective synthesis of (2S,3S)-3-hydroxypipecolic acid 1 starting from 1,4-butanediol using Sharpless asymmetric dihydroxylation and the regioselective nucleophilic opening of a cyclic sulfate as the key steps is described. |
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