Photolysis of NSAIDs. Part 3: Structural elucidation of photoproducts of tolmetin in methanol |
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| Authors: | Ming-Thau Sheu Chih-Jui Chen An-Bang Wu |
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| Institution: | a Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
b Department of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan |
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| Abstract: | A sample of 10 mM tolmetin in methanol was photo-irradiated with a Hanovia 200 W high-pressure quartz Hg lamp for four days. In total, eight photoproducts were observed from the HPLC chromatogram. Three major photoproducts were separated, and their structures were elucidated by spectroscopic methods. The structures of all photoproducts were further determined by LC-ESI-MS. A reaction scheme of tolmetin was proposed. |
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| Keywords: | Tolmetin Photoproducts LC-ESI-MS |
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