Angular hydroxymethyl directed intramolecular Diels-Alder approach for the stereo- and regioselective synthesis of pimaraditerpenes |
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| Authors: | Nam Song Choi Young-Ger Suh |
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| Affiliation: | a Research Institute of Pharmaceutical Science, College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, Korea
b College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea |
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| Abstract: | The stereo- and regioselective synthetic route to pimaraditerpenes, employing an angular hydroxymethyl directed intramolecular Diels-Alder reaction of the decaline intermediate, has been developed. This synthetic approach allows prompt access to both natural pimaraditerpenes and the unnatural regioisomers, which would be potentially new anti-inflammatory pimaraditerpenes. |
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| Keywords: | Pimaraditerpene Anti-inflammation Intramolecular Diels-Alder reaction |
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