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A novel deprotection of trichloroacetamide |
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| Authors: | Daisuke Urabe Toshio Nishikawa Minoru Isobe |
| Affiliation: | a Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan b PRESTO, Japan Science and Technology Agency (JST), H-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan |
| Abstract: | Deprotection of trichloroacetamide was carried out with Cs2CO3 in DMF or DMSO at 100 °C to afford an amine in good yield. A survey of the scope and limitations revealed the utility of the deprotection condition for various functionalized substrates. |
| Keywords: | Protecting group Deprotection Trichloroacetamide Overman rearrangement |
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