Lewis acid-catalyzed one-pot crossed Prins cyclizations using allylchlorosilane as allylating agent |
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| Authors: | Kok-Ping Chan |
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| Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore |
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| Abstract: | A one-pot multi-component Lewis acid-catalyzed Prins cyclization was developed with high yield and selectivity. The crossed 2,4,6-trisubstituted tetrahydropyran products were formed with high stereoselectivity. This catalytic method could also be used with α,β-unsaturated aldehydes affording moderate yields of products. |
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| Keywords: | Tetrahydropyran Prins cyclization In(OTf)3 InCl3 |
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