Synthesis of diarylmethane derivatives from Pd-catalyzed cross-coupling reactions of benzylic halides with arylboronic acids |
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Authors: | Sabrina M Nobre |
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Abstract: | A simple catalyst precursor prepared in situ from palladium acetate and triphenylphosphine shows high activity for the Suzuki cross-coupling reaction of benzylic bromides and chlorides with aryl boronic acids. The reaction can be carried out at low catalyst loading (0.002-1 mol%) and under mild conditions (room temperature to 80 °C) furnishing diarylmethane derivatives in high yields (86-99%). |
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Keywords: | Benzylic halides Suzuki cross-coupling reaction Diarylmethanes |
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