Controlling selectivity: from Markovnikov to anti-Markovnikov hydroamination of alkynes |
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| Authors: | Annegret Tillack |
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| Affiliation: | Leibniz-Institut für Organische Katalyse (IfOK) an der Universität Rostock e.V., Buchbinderstr. 5-6, D-18055 Rostock, Germany |
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| Abstract: | Depending on the catalyst a remarkable control of regioselectivity is achieved for the titanium-catalyzed intermolecular hydroamination of various alkynes. Proper choice of sterically hindered phenol ligands such as 1 and 4 enables a selectivity switch from the Markovnikov to the anti-Markovnikov products from M:anti-M = > 90:10 to > 10:90. |
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