Syntheses of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones: intermediates in the synthesis of aprepitant |
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| Authors: | Todd D. Nelson Jonathan D. Rosen Bridgette Craig James M. McNamara |
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| Affiliation: | a Merck Research Laboratories, Department of Process Research, Merck & Co., 466 Devon Park Drive,Wayne, PA 19087, USA
b Merck Research Laboratories, Department of Process Research, 126 East Lincoln Avenue, Rahway, NJ 07065, USA |
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| Abstract: | The preparation of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones from N-substituted β-amino alcohols is reported. These were useful intermediates in the synthesis and development of aprepitant. |
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| Keywords: | Morpholine-3-ones Morpholine-2,3-diones Amino alcohols Lactol Lactam |
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