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Enantioselective addition of phenyl and alkyl acetylenes to imines catalyzed by chiral Cu(I) complexes |
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| Authors: | Maurizio Benaglia Diego Negri Gianmaria Dell’Anna |
| Institution: | Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, via Golgi 19, 20133 Milan, Italy |
| Abstract: | The stereoselective addition of phenyl acetylene and alkyl acetylenes to imines, catalyzed by chiral bis-imines-Cu(I) complexes was studied. A very simple experimental procedure allowed to obtain at room temperature optically active propargyl amines in very good yields and enantioselectivity up to 81%. |
| Keywords: | Propargyl amines Chiral bis-imines Acetylenes addition Chiral ligands Asymmetric catalysis |
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