A mild and highly efficient protocol for the one-pot synthesis of primary α-amino phosphonates under solvent-free conditions |
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Authors: | Najmedin Azizi |
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Institution: | Department of Chemistry, Sharif University of Technology, PO Box 11365-9516, Tehran 11365, Iran |
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Abstract: | Under solvent-free reaction conditions and in the presence of solid LiClO4 a novel and mild protocol for the one-pot, three-component synthesis of primary α-amino phosphonates from an aldehyde, hexamethyldisilazane and a trialkyl phosphite is described giving high yields and having short reaction times. The same products are obtained in very low yields, when the three-component reaction is carried out under microwave irradiation and in the absence of solid LiClO4. Examples of some prepared 1-aryl-N,N′-bis(arylidene)methanediamines are also described. |
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