Total synthesis of (+)-bongkrekic acid |
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| Authors: | Mitsuru Shindo Tomoyuki Sugioka |
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| Affiliation: | Institute for Medicinal Resources, University of Tokushima, Sho-machi 1, Tokushima 770-8505, Japan |
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| Abstract: | Total synthesis of bongkrekic acid, an important apoptosis inhibitor, has been accomplished. The strategy includes inexpensive starting materials, asymmetric alkylation, anionic allyl coupling and oxidative manipulations. This process would provide a sufficient amount of bongkrekic acid and its analogues. |
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| Keywords: | Apoptosis Carboxylic acid Oxidation Natural product Total synthesis |
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