Reductive alkylation of thioureas: a highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas |
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| Authors: | Lech Ciszewski Daquiang Xu Oljan Repi? Thomas J Blacklock |
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| Institution: | Process R&D, Chemical and Analytical Development, Novartis Institute for Biomedical Research, East Hanover, NJ 07936, USA |
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| Abstract: | A highly practical synthesis of unsymmetrical N,N′-disubstituted thioureas by the reductive alkylation of N-monosubstituted thioureas with aldehydes is described. N-Monosubstituted thioureas can in turn be synthesized by the reductive amination of thiourea with an appropriate aldehyde. This reductive alkylation methodology was also extended to carbamates. |
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