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A simplified green chemistry approach to the Biginelli reaction using ‘Grindstone Chemistry’ |
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| Authors: | Ajay K Bose Suhas Pednekar Goutam Chakraborty |
| Institution: | a George Barasch Bioorganic Research Laboratory, Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA b Department of Chemistry and Biochemistry, Montclair State University, Montclair, NJ 07043, USA |
| Abstract: | Grindstone Chemistry--a greatly evolved version of Toda’s method of grinding solids together for solvent-free chemical reactions--has been described and its usefulness illustrated by the successful application of this technique to a simplified process for conducting the multi-component Biginelli reaction for the synthesis of physiologically active tetrahydropyrimidinones. |
| Keywords: | Tetrahydropyrimidinone Reaction by grinding Solvent-free reaction p-TSA as an acid catalyst |
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