The synthesis of potential Neramexane metabolites: cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids |
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| Authors: | Dina Trifanova Aigars Jirgensons Valerjans Kauss Ivars Kalvinsh |
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| Affiliation: | a Latvian Institute of Organic Synthesis, 21 Aizkraukles str., 1006 Riga, Latvia
b Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, D-60318 Frankfurt am Main, Germany |
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| Abstract: | A seven step synthetic route toward potential Neramexane metabolites cis- and trans-3-amino-1,3,5,5-tetramethylcyclohexanecarboxylic acids, cis-1 and trans-1, has been developed from isophorone. The synthetic procedure represents a useful method for the preparation of γ-amino acids with both amino and carboxyl groups situated at tertiary carbon atoms. |
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| Keywords: | Neramexane Metabolites The Ritter reaction Latent carboxyl group Oxidation |
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