Potassium iodide catalysed monoalkylation of anilines under microwave irradiation |
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| Authors: | Juan L. Romera,José M. Cid,André s A. Trabanco |
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| Affiliation: | Johnson and Johnson Pharmaceutical Research and Development, A Division of Janssen-Cilag S.A., Jarama s/n, 45007 Toledo, Spain |
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| Abstract: | A potassium iodide catalysed method for the selective N-monoalkylation anilines with alkylhalides and alkyltosylates under microwave irradiation is described. The corresponding N-alkylanilines are obtained in good yields with only minor quantities of dialkylation by-products. |
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| Keywords: | Microwave assisted synthesis Aniline N-Alkylation |
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