Synthesis of tripeptides containing a very crowded α,α-disubstituted glycine with pyridine rings by solid-phase Ugi reaction |
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| Authors: | Masayuki Hanyu |
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| Institution: | Department of Chemistry, Faculty of Science and Engineering, Konan University, Higashinada-ku, Kobe 658-8501, Japan |
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| Abstract: | Tripeptides containing a novel α,α-disubstituted glycine with two pyridine rings, α,α-di(2-pyridyl)glycine (2Dpy), were synthesized by the solid-phase Ugi reaction using di(2-pyridyl)methanimine attached directly to a Rink amide resin. Thereby, yields of the tripeptides, Z-AA1-2Dpy-AA3-OMe (AA1 and AA3 = Gly or Aib), were markedly improved, compared with yields by the solution method. |
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| Keywords: | α α-Disubstituted glycine α α-Di(2-pyridyl)glycine (2Dpy) α α-Diphenylglycine (Dph) Solid-phase synthesis Ugi reaction |
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